Chinese vaccine developers gain WHO imprimatur

8th vaccine renaissance: A creative nexus for vaccine developers.

Who are the users ? Who are the developers ? Webs of users and developers in the development process of a technical

The paper presents an empirical study of user involvement in developing a technical standard for a scientific community’s information system project. The case illustrates how multiple perspectives are involved when considering the user role in practice. The case presents a situation where both developers and users were pre-defined in the design and development phases of the standard as homogene...

Dengue vaccine: WHO position

Beatty ME, et al. Health economics of dengue: a systematic literature review and expert panel's assessment. Am J Trop Med Hyg. 2011;84(3):473-88. Dengue vaccines are currently in development and policymakers need appropriate economic studies to determine their potential financial and public health impact. We searched five databases (PubMed, EMBASE, LILAC, EconLit, and WHOLIS) to identify health...

Dengue: Challenges for Policy Makers and Vaccine Developers

Because of the increasing incidence, geographic expansion and economic burden of dengue transmission, dengue poses major challenges to policy makers. A vaccine against dengue is urgently needed, but vaccine development has been hampered by the lack of an appropriate animal model, poor understanding of correlates of successful human immunity, the fear of immune enhancement, and viral interferenc...

IL-33, Imprimatur of Adipocyte Thermogenesis

Chawla and colleagues find that interleukin-33 is a critical controller of brown and beige adipocyte thermogenesis. Its primary impact is on the splicing of transcripts encoding uncoupling protein-1, resulting in uncoupled respiration and effective heat generation. Interleukin-33 acts perinatally to ensure adaptive thermogenesis lifelong.